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AURORA KA-645

Nitazoxanide

CAS: 55981-09-4

Molecular Formula: C12H9N3O5S

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AURORA KA-645 - Names and Identifiers

Name Nitazoxanide
Synonyms BRN 1225475
Nitazoxanide
NITAZOXANIDE
AURORA KA-645
2-(acetyloxy)-n-(5-nitro-2-thiazolyl)-benzamid
2-(acetolyloxy)-n-(5-nitro-2-thiazolyl)benzamide
n-(5-nitro-2-thiazolyl)salicylamideacetate(ester)
n-(5-nitro-2-thiazolyl)-salicylamidacetate(ester)
o-[n-(5-nitrothiazol-2-yl)carbamoyl]phenyl acetate
CAS 55981-09-4
EINECS 259-931-8
InChI InChI=1/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

AURORA KA-645 - Physico-chemical Properties

Molecular FormulaC12H9N3O5S
Molar Mass307.28
Density1.629 g/cm3
Melting Point202°C
Solubility Soluble in DMSO (>50 mg/ml)
AppearanceLight yellow or white solid
ColorOff-white
Maximum wavelength(λmax)['416nm(Phosphate buffer sol.)(lit.)']
Merck14,6567
pKa6.18±0.50(Predicted)
Storage Condition2-8°C
StabilityStable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
In vitro studyIn cell culture, Nitazoxanide reduced parasite growth by more than 90%, with no signs of human and drug-related cytotoxicity. Nitazoxanide is a new parasite repellent of thiazolide, showing excellent in vitro activity against a variety of protozoa and helminths. Nitazoxanide and its metabolite tizoxanide are more potent than metronidazole against G. intestinalis, E. histolytica and T. vaginalis in vitro. Nitazoxanide showed potent inhibition of HBV and HCV replication. In replicon-containing cells of HCV, Nitazoxanide made subsequent treatment with Nitazoxanide plus interferon more effective, but did not enhance the effect of Nitazoxanide plus 2'CmeC. Nitazoxanide induces a decrease in the production of several HBV proteins (HBsAg and HBBeag, core antigens) in 2.2.15 cells, but does not affect the transcription of HBV RNA. Nitazoxanide showed a right to E. The IC50 and IC90 values of histolytica were 0.017 mg/mL and 0.776 mg/mL, respectively. intestinalis 0.004 mg/mL and 0.067 mg/mL, respectively, against T. vaginalis. 0.034 mg/mL and 2.046 mg/mL, respectively. Nitazoxanide was more toxic to Entamoeba histolytica than Metronidazole and Propimazole.
In vivo studyIn a sterile piglet model of diarrhea, oral treatment with Nitazoxanide(250 mg/kg) reduced the number of parasites after 11 days. Nitazoxanide induced a drug-associated diarrhea that may have affected its therapeutic efficacy.

AURORA KA-645 - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany3
RTECSVN7830000
HS Code2934100000
ToxicityLD50 orally in male, female mice: 1350, 1380 mg/kg; in rats: >10 g/kg (Murphy, Friedmann)

AURORA KA-645 - Reference

Reference
Show more
1. Li Yafen, Zhao Jun, LV Guodong, et al. Study on the anti-Echinococcus granulosus mechanism of Veliparib combined with artesunate in vitro [J]. Chinese Journal of pathogenic biology, 2018v.13;No.139(07):59-65.
2. Zheng Haiya, Wen Limei, Lu Guodong, etc. Study on the effect of artesunate against Echinococcus granulosus active oxygen on DNA mechanism in vitro [J]. Chinese Journal of pathogenic biology, 2017, 29 (08):751-756.
3. [IF = 5.31] Fanghua Gong et al."Nitazoxanide induced myocardial injury in zebra fish embyos by activating." J Cell Mol Med. 2021 Oct;25(20):9740-9752

AURORA KA-645 - Reference Information

Application nitazoxanide as a highly efficient, broad-spectrum anti-parasitic, drugs for bacterial and fungal infections are of widespread interest, and it is the first and only drug approved by the U. S. Drug and Food Administration (FDA) for the treatment of cryptosporidium.
Use in vitro studies have shown that nitazoxanide has broad-spectrum antibacterial and antiparasitic effects, and can be used to treat amoeba dysentery, infections caused by worms such as giardia, Trichomonas vaginalis, and protozoa and bacteria such as Campylobacter jejuni, Clostridium difficile, Clostridium perfringens, and Helicobacter pylori. Nitazoxanide is used to treat children with ascariasis and hymeniasis. It has similar effects to albendazole and praziquantel.
biological activity nitazoxide (NTZ, NSC 697855) is a synthetic nitrothiazolyl-salicylamide derivative, is an antigenic insect (for canine influenza Virus, IC50 0.17 to 0.21 μm). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling.
TargetValue
Last Update：2024-04-10 22:41:30
AURORA KA-645
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Nitazoxanide Request for quotation
CAS: 55981-09-4
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Shanghai Yuanye Bio-Technology Co., Ltd.
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Product Name: Nitazoxanide Visit Supplier Webpage Request for quotation
CAS: 55981-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Nitazoxanide Request for quotation
CAS: 55981-09-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Nitazoxanide Visit Supplier Webpage Request for quotation
CAS: 55981-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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AURORA KA-645
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